Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol). This compound has unique chemical properties. The synthetic route is as follows. Formula: C4H10O3
General procedure: Potassium tert-butoxide (x100 = 11.1 mmol, x1500 = 0.67 mmol, x6000 = 1.42 mmoL) was added to dissolved PEGx (x100 = 21.4 mmol, x1500 = 1.33 mmoL, x6000 = 0.50 mmoL) in dry tetrahydrofuran (20 mL,x100 or x1500) or dimethylformamide (20 mL, x6000, dissolution of PEG by heating) at 0 C. After 15 min,the mixture was allowed to warm to room temperature and stirred for 30 min. Propargyl bromide was added (x100 = 13.4, mmol, x1500 = 0.67 mmoL, x6000 = 1.98 mmol) and the mixture was stirred overnight for 14 h at the same temperature. The fine solids were filtered off through a membrane filter and the solution was concentrated in vacuo to a minimum volume. In the case of the mixture containing PEG 6000, the reaction was stopped by dilution with dichloromethane (30 mL), the residue was precipitated with diethylether (3 × (5-10) mL), diethylether was decanted and the product was dried on an oil pump.2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanol (4a) Yield 2.23 g (91%) of pale yellow liquid. 1H NMR (CDCl3):delta 2.45 (t, J = 2.3, 2H, CH2CCH), 3.58-3.67 (m, 2H, CH2OH), 3.69-3.78 (m, 6H, CH2O), 4.22 (d, J = 2.4,2H, CH2CCH). 13C NMR (CDCl3): delta 58.6 (CH2CCH). 61.9, 69.3, 70.4, 72.6 (CH2O), 74.8 (CH2CCH), 79.6(CH2CCH). The spectroscopic data of 5a are in agreement with [26].
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Reference:
Article; Pomeisl, Karel; Richter, Jan; Golan, Martin; Kratochvilova, Irena; Molecules; vol. 25; 3; (2020);,
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