Related Products of 7735-42-4 ,Some common heterocyclic compound, 7735-42-4, molecular formula is C16H34O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The diol (1 eq.) and 100 mL acetonitrile were placed in a 200 mL beaker with a stirring element. The mixture was re-heated to a temperature of 50C, after which copper complex [Cu(MeCN)4]PF6 (10 mol%), TEMPO (10 mol%) 2,2′-bipyridyl (10 mol%) and 1 -methylimidazole (20 mol%) were added one by one. The reaction was conducted for 4 hours until the substrate disappeared. Afterwards, the whole was evaporated and dissolved in methylene chloride, and SnachCat solution was then added. After stirring, the solution was filtered (through Si02), washing it with methylene chloride, and then the solution was evaporated. (0814) Hexyl triphenylphosphine bromide (2.1 eq.) was dissolved in 120 mL tetrahydrofuran under the atymosphere of argon in a 250 mL single-necked round flask. 2.5M solution of n-butyllithium in hexane (2.1 eq) was added dropwise to the resulting mixture, and allowed to rest while stirring for 30 minutes. The resulting solution was cooled to 0C, and the previously obtained aldehyde in a solution of tetrahydrofuran (1 eq.) was slowly added dropwise. The reaction mixture was heated to room temperature and then stirring was continued for another 2 hours at room temperature. 50 mL of saturated ammonium chloride solution was then added. The mixture was washed four times with methylene chloride. The combined ether layers were dried over MgS04. The product was purified by chromatography using n- hexane. A colourless oil was obtained. 75% yield. (0815) 1 H NMR (400 MHz, CDCI3) 5.46 – 5.27 (m, 4H), 2.10 – 1 .90 (m, 8H), 1 .44 – 1 .16 (m, 36H), 0.97 – 0.80 (m, 6H); 13C NMR (101 MHz, CDCI3) delta 130.05, 130.04, 31 .69, 29.93, 29.85, 29.82, 29.73, 29.62, 29.48, 27.36, 27.33, 22.75, 14.25
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7735-42-4, 1,16-Hexadecanediol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIWERSYTET WARSZAWSKI; GRELA, Karol; CZARNOCKA-?NIAD?A, Sylwia; SYTNICZUK, Adrian; MILEWSKI, Mariusz; URBAN, Mateusz; BANACH, ?ukasz; D?BROWSKI, Micha?; (109 pag.)WO2018/197963; (2018); A1;,
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