Adding a certain compound to certain chemical reactions, such as: 23147-58-2, Glycerol aldehyde dimer, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H8O4, blongs to alcohols-buliding-blocks compound. Formula: C4H8O4
Step 2: (S)-2-Amino-N-[(S)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-butyramide was dissolved in MeOH (2 mL) and15 glycolaldehyde dimer (10.9 mg, 90.5 ).IDOl, Eq: 0.55), acetic acid (9.5 )lL, 165 ).IDOl, Eq: 1.0) andsodium cyanoborohydride (15.5 mg, 247 ).IDOl, Eq: 1.5) were successively added. The mixturewas stirred at RT overnight. The mixture was diluted with 1 N HCl, 1 N NaOH added to adjust thepH to ca. 11. The mixture was extracted with EtOAc, the extracts washed with brine, dried overNa2S04, concentrated and the resulting material purified by flash chromatography to afford the20 title compound which was lyophilized from MeCN/H20 (55 mg, 60 %). MS m/z 556.0 (MH+
The synthetic route of 23147-58-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HAN, Xiaochun; LOU, Yan; MICHOUD, Christophe; MISCHKE, Steven Gregory; REMISZEWSKI, Stacy; RUPERT, Kenneth Carey; WO2014/9495; (2014); A1;,
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