Synthetic Route of 1462-03-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1462-03-9, name is 1-Methylcyclopentanol. A new synthetic method of this compound is introduced below.
1-methylcyclopentanol (2 mmol), catalytic amounts of the ionic liquid, and 1-2 mL of acetic acid were charged into an oven-dried Schlenk tube under nitrogen. The reaction mass was stirred for 15-20 minutes at r.t. before adding the selected nitrile (1 mmol). The reaction mass was stirred at the indicated temperature for the specified time (see Table 3). The progress of the reaction was monitored by TLC and GC-MS. After completion of reaction, the reaction mass was quenched with distilled water followed by neutralization with dilute NaHCO3 solution. The product was extracted with diethyl ether, dried over anhydrous MgSO4, and the ether layer was evaporated in vacuum. The resulting crude products were chromatographed with hexane-ethyl acetate mixture (80:20) to afford pure colorless solids.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1462-03-9, its application will become more common.
Reference:
Article; Kalkhambkar, Rajesh G.; Waters, Sarah N.; Laali, Kenneth K.; Tetrahedron Letters; vol. 52; 8; (2011); p. 867 – 871;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts