With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.153599-45-2, name is Methyl 3-(2-hydroxyethyl)benzoate, molecular formula is C10H12O3, molecular weight is 180.2, as common compound, the synthetic route is as follows.Computed Properties of C10H12O3
To a stirred solution of methyl 3- (2-hydroxyethyl) benzoate (10 g) in anhydrous dichloromethane (90 mL) at 0 C was added methanesulfonyl chloride (34 g, 299 mmol) And triethylamine (12 g, 118 mmol).The reaction was stirred at 0 C for 1 hour, quenched with water (50 ml)And extracted with ethyl acetate (100 ml x 3). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 10% ethyl acetate in petroleum ether)To give 2.7 g of methyl 3- (2 – ((methylsulfonyl) oxy) ethyl) benzoate as a colorless oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,153599-45-2, Methyl 3-(2-hydroxyethyl)benzoate, and friends who are interested can also refer to it.
Reference:
Patent; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; DING, ZHAO ZHONG; WU, HAO; SUN, FEI; WU, LI FANG; YANG, LING; (97 pag.)TWI558709; (2016); B;,
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