Application of 7250-55-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7250-55-7 as follows.
To a stirred solution of dimethyl 3-hydroxyglutarate (19.98 g, 113.4mmol) in THF (340 mL) under argon at room temperature was added BH3·Me2S (3 equiv., 32.26 mL, 340.1 mmol) drop to drop. After 48 h the reaction mixture was diluted with MeOH (340 mL) with intense formation of bubbles, and stirred morefor 1 h. The solvent was distilled off and the residue purified by column chromatography on silica gel (EtOAc to MeOH/EtOAc, 1:9) to afford pentane-1,3,5-triol (2) (12.30g, 90%) as a colorless oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7250-55-7, its application will become more common.
Reference:
Article; Kang, Young-Goo; Park, Chan-Yong; Shin, Hongsuk; Singh, Ramandeep; Arora, Garima; Yu, Chan-Mo; Lee, Ill Young; Bioorganic and Medicinal Chemistry Letters; vol. 25; 17; (2015); p. 3650 – 3653;,
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