Reference of 3637-61-4 ,Some common heterocyclic compound, 3637-61-4, molecular formula is C6H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The toluene 4-sulfonic acid cyclopentyl methyl ester was prepared by adding p- Toluenesulfonyl chloride (3.6 mmol, 684 mg) to a solution of CYCLOPENTANEMETHANOL (3 mmol, 300mg) and pyridine (3ml) in dichloromethane (3ml). The resulting mixture was stirred for 2 1/2 hours at room temperature, then diluted with DICHLOROMETHANE and washed sequentially with HCI (1 M solution) and a saturated solution of NA2CO3. The organic layer was then dried over MgSO4 and evaporated to give the TOLUENE-4-SULFONIC acid cyclopentyl methyl ester.1H NMR (CDCI3) delta 1.17 (2H, m), 1.53 (4H, m), 1.69 (2H, m), 2.20 (1H, m), 2.45 (3H, s), 3.89 (2H, d), 7.34 (2H, d), 7.78 (2H, d).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3637-61-4, Cyclopentanemethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/39753; (2004); A2;,
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