With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, molecular weight is 123.1525, as common compound, the synthetic route is as follows.623-04-1
To a solution of (4-Aminophenyl)methanol (1.50 g, 12.18 mmol) in CH2CI2 (20 ml.) was added TBDMSCI (1.84 g, 12.18 mmol) and imidazole (0.91 g, 13.40 mmol). After stirring for 1 h at room temperature, the solution was diluted with brine, and extracted with E-tOAc. The organic extract was dried (Na2SO4), filtered, and evaporated. The residue was purified by silica gel column chromatography with gradient of EtOAc (25-100%) in Hexane to afford 67 (2.76 g, 96%) as a light yellow oil. LRMS (ESI): (calc.) 237.4; (found) 238.2 (MH) +
Statistics shows that 623-04-1 is playing an increasingly important role. we look forward to future research findings about (4-Aminophenyl)methanol.
Reference:
Patent; METHYLGENE INC.; WO2006/102760; (2006); A1;,
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