Related Products of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.
Procedure 1, Step A. To a solution of 2-(4-aminophenyl)-l, l,l,3,3,3-hexafluoropropan-2- ol (4) (15 g, 1.0 equiv) in DMF (120 mL) was added a solution of NaN02(4.4 g, 1.1 equiv) in 30 mL water. The mixture was cooled to 0C for 15 min. 6 N HC1 (29 mL, 3.0 equiv) was added dropwise to the reaction mixture for over 15 min at 0C. The resulting mixture was stirred at 0C for lh. KI (10.1 g, 1.05 equiv) was added with portions (over 15 mins). The reaction mixture was stirred at 0C for lh, and then at room temperature overnight. The reaction was diluted with water (-500 mL) and extracted with EtOAc/hexane (2: 1, 3 x 150 mL). The combined organic phase was washed with NaHS03, water, and brine. The crude mixture was purified on a silica gel column to afford l, l,l,3,3,3-hexafluoro-2-(4-iodophenyl)propan-2-ol (Intermediate 1) (18.85 g, yield 88%) as a pale yellow oil.
According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ESCALIER BIOSCIENCES B.V.; MOHAN, Raju; NUSS, John; HARRIS, Jason; YUAN, Shendong; (144 pag.)WO2019/177996; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts