Related Products of 1805-32-9 ,Some common heterocyclic compound, 1805-32-9, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a 50 mL Schlenk tube equipped with a stir bar was added 0.5 mmol of benzylic alcohol followed by 0.05 mmol of CuF2 (0.1 equiv). The mixture of DMSO (1.5 mL) and H2O (1.5 mL) was added, followed by 6 mmol of TBHP(12 equiv). The glass tube was vacuumed and purged with argon three times before it was tightly screw-capped. The reaction mixture was stirred at 120 Cfor 12 h, cooled to room temperature, poured into brine and extracted with EtOAc. The combined extracts were dried over MgSO4, filtered, and evaporated. The residue was purified by column chromatography (petroleumether/EtOAc) to afford the methyl ester
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1805-32-9, 3,4-Dichlorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Li, Pan; Zhao, Jingjing; Lang, Rui; Xia, Chungu; Li, Fuwei; Tetrahedron Letters; vol. 55; 2; (2014); p. 390 – 393;,
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