In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol), the common compound, a new synthetic route is introduced below. Recommanded Product: 111-46-6
1.122 g of tBuOK (potassium tert-butoxide) was dissolved in 6.5 ml of dry THF (tetrahydrofuran)2.12g of diethylene glycol was added under the protection of ice-water outer bath under argon, the reaction was stirred for 30 minutes, then 1.18g of bromopropyne was added dropwise,The reaction was complete after dropping 1 hour ice water bath, the reaction was carried out at room temperature for 12 hours, the reaction was stopped after diatomaceous earth filter layer, the filtrate evaporated to give a yellow oil, 300-400 mesh silica gel medium pressure separation,The mobile phase of petroleum ether: ethyl acetate = 4: 1, the product fractions were collected and evaporated to give the product 0.976g pale yellow oily product, yield 72.8%.
The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
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