Application of 873-76-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 873-76-7, name is (4-Chlorophenyl)methanol. A new synthetic method of this compound is introduced below.
General procedure: Reactants used were p-methylbenzyl alcohol (122.03g, 1000mmol, i.e., of formula (I) wherein R is methyl, n = 1, m = 0 , X = C),cuprous iodide (9.50 g of , 50mmol), N- phenylglycine (7.51g, 50mmol), TEMPO ( 7.80g, 50mmol),sodium hydroxide (4.00g, 100mmol), aqueous ammonia (300mL, 25 ~ 28%) ,ethanol, 800mL, in an ice bath under the condition, with oxygen round bottom flask is evacuated of air ventilation 3 times, and then the system was stirred at 25 , 24h, after completion of the reaction, the reaction solution was cooled to room temperature, rotary evaporated to remove the solvent, the residue was washed with water filtered and dried The product was 107.64g, yield 92%. The reaction was used for the chlorobenzyl alcohol (28.40g, 200mmol, i.e., of formula (I) wherein R is 4-chloro, X = C, n = 1 , m = 0), the same experimental methods and procedures of Example 2, except that: Cuprous iodide(1.90g, 10mmol), N- phenyl-phenylalanine (2.41g, 10mmol), TEMPO ( 1.56g, 10mmol), sodium hydroxide (0.80g, 20mmol), aqueous ammonia (60mL, 25 ~ 28%) , ethanol 160mL, under condition of 80 stirred for 24h, to give the final product 24.66g, yield 90%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,873-76-7, (4-Chlorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang University of Technology; Zhang, Guofu; Zhang, Guihua; Ding, Chengrong; Li, Shasha; Xu, Shengjun; Shan, Shang; (9 pag.)CN105294646; (2016); A;,
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