The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 455-01-6, name is 2-(3-(Trifluoromethyl)phenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 455-01-6
Example 86 3-(Trifluoromethyl)phenethyl N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}carbamate 2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]aniline (85 mg) was added to toluene/triethylamine = 10/1 (9 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (125 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethylphenethyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (69 mg, yield 46%). 1H-NMR (CDCl3, 400 MHz): 8.79 (1H, s), 8.27 – 8.34 (1H, m), 8.03 (1H, s), 7.30 – 7.62 (6H, m), 7.24 – 7.23 (2H, m), 4.46 (2H, t, J = 6.8 Hz), 4.18 (3H, s), 4.11 (3H, s), 3.10 (2H, t, J = 6.9 Hz) Mass spectrometry value (ESI-MS, m/z): 549 (M++1)
With the rapid development of chemical substances, we look forward to future research findings about 455-01-6.
Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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