Electric Literature of 505-10-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.505-10-2, name is 3-(Methylthio)propan-1-ol, molecular formula is C4H10OS, molecular weight is 106.19, as common compound, the synthetic route is as follows.
The alcohol 23-a (200 g, 1900 mmol) was dissolved in CH2Cl2 (2000 ml). The mixture was cooled to 0 C. The m-CPBA 85% in water (970 g, 5700 mmol) was added portion wise keeping the temperature between 0 to 5 C. After addition, the mixture was allowed to warm to 25 C. and stirred for 15 h. The mixture was filtered through a celite pad. The filtrate was purified by flash column (Eluent: petroleum ether:ethyl acetate=3:1 and then ethyl acetate: methanol=10:1) to yield the intermediate 23-b (75 g, 29%).
Statistics shows that 505-10-2 is playing an increasingly important role. we look forward to future research findings about 3-(Methylthio)propan-1-ol.
Reference:
Patent; Jansen R&D Ireland; Tahri, Abdellah; Jonckers, Tim Hugo Maria; Raboisson, Pierre Jean-Marie Bernard; Vendeville, Sandrine Marie Helene; Hu, Lili; Demin, Samuel Dominique; Cooymans, Ludwig Paul; US2015/111868; (2015); A1;,
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