Synthetic Route of 4254-29-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol. A new synthetic method of this compound is introduced below.
General procedure: General Procedure C A flame-dried flask with Teflon stir bar was charged with triphenylphosphine (1.2 equiv.) and I2(1.2 equiv.) in CH2Cl2, the mixture was stirred for 10 min at room temperature. Imidazole (1.2equiv.) was added to the resulting mixture. After 10 min of stirring, the corresponding alcohol(1.0 equiv.) was added and the reaction was stirred for additional 5 h at room temperature andwas checked by TLC until completion. The reaction mixture was quenched with Sat. Na2SO3.The mixture was transferred to a separatory funnel using CH2Cl2 and brine to aid the transferand separation. The aqueous and organic layers were separated and the aqueous layer wasextracted by CH2Cl2 (3x). The combined organic layers were washed with brine and dried overNa2SO4, filtered, and concentrated in vacuum. The crude reaction mixture was purified by flashchromatograph on silica gel and evaporated to give the alkyl iodide compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4254-29-9, its application will become more common.
Reference:
Article; Bai, Songlin; Gao, Yadong; Jiang, Chao; Liu, Xiaolei; Qi, Xiangbing; Wang, Jing; Wu, Qingcui; Yang, Chao; Chem; vol. 6; 3; (2020); p. 675 – 688;,
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