Synthetic Route of 100058-61-5 ,Some common heterocyclic compound, 100058-61-5, molecular formula is C11H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine 31-a (392 mg, 2.5 mmol) and Intermediate 31-b (500 mg, 2.8 mmol) in THF (12.7 mL) were sequentially added triphenylphosphine (2.0 g, 7.6 mmol), and DIAD (1.5 ml, 7.6 mmol). The solution was stirred at room temperature for 1 hour. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided Intermediate 5-c as a beige oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100058-61-5, 3-(Benzyloxy)cyclobutanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PHARMASCIENCE INC.; LAURENT, Alain; ROSE, Yannick; WO2015/77866; (2015); A1;,
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