Synthetic Route of 616-29-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 616-29-5, name is 1,3-Diaminopropan-2-ol. A new synthetic method of this compound is introduced below.
N- (3-CARBOXY-6-METHYLPHENYL)-S-METHYLISOTHIOUREA (17.0 g, 0.048 mol) and 1,3-diamino-2-hydroxypropane (12.96 g, 0.144 mol) and DMF (20 mL) were added to 200 mL flask equipped with condenser and drying tube. The solution was heated at 100 C for 36 h and was cooled and filtered. The solid was washed with ethyl acetate, then ether. The solid was added slowly to stirring 4N HCI in dioxane. The mixture was stirred for 2h. The reaction mixture became difficult to stir and the solution was concentrated and dried under high vacuum overnight. The solid was washed with ether three times, filtered, and dried. Yield 13. 31G (97%) 1H NMR (CD30D) a 7.13-7. 21 (m, 2H), 6.86 (m, 1H), 3.26 (m, 4H), 1.83 (m, 2H). Anal. Calcd for C11H1303N3 : MOL. Wt, 236.1005 (M+H, HRMS). Found: MOL. W, 236.1035 (M+H, HRMS).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,616-29-5, 1,3-Diaminopropan-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; PHARMACIA CORPRATION; WO2004/60376; (2004); A1;,
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