With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol, molecular formula is C7H6BrClO, molecular weight is 221.48, as common compound, the synthetic route is as follows.Recommanded Product: 60666-70-8
Synthesis of l-bromo-4-chloro-2-(methoxymethyl)benzene 6c [00180] To a solution of (2-bromo-5-chloro-phenyl)methanol (3.16 g, 14.25 mmol) in THF (50 mL) at room temperature was added sodium hydride (684 mg, 17.10 mmol). The mixture was stirred for 30 min and then iodomethane (3.04 g, 1.33 mL, 21.38 mmol) was added and the reaction stirred overnight. The mixture was diluted with saturated aqueous ammonium chloride and EtOAc and the organic washed with water, then brine, and dried ( a2S04) and concentrated to afford the title compound 6c as an oil (3.36 g, quant). XH NMR (500 MHz, CDC13) delta 7.40 – 7.48 (2H, m), 7.1 1 – 7.14 (1H, m), 4.47 (2H, s), 3.48 (3H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,60666-70-8, (2-Bromo-5-chlorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; BOYALL, Dean; DAVIS, Christopher; DODD, James; EVERITT, Simon; MILLER, Andrew; WEBER, Peter; WESTCOTT, James; YOUNG, Stephen; WO2014/81689; (2014); A1;,
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