Adding a certain compound to certain chemical reactions, such as: 15852-73-0, (3-Bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 15852-73-0, blongs to alcohols-buliding-blocks compound. Formula: C7H7BrO
To a solution of 3-bromobenzyl alcohol (3.00 g, 16.0 mmol) and triethylamine (2.91 mL, 20.9 mmol) indichloromethane (50 mL) at 0 °C was added methanesulfonyl chloride drop-wise. After 2 h, the reaction mixture was washed with saturated aqueous sodium bicarbonate solution and water. The organic layer was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford the title compound as a light yellow oil.Yield: 4.3 g, 16 mmol, 100percent. 1H NMR (400 MHz, CDCI3) oe 2.99 (5, 3H), 5.21 (5, 2H),7.30 (dd, J=7.8, 7.7 Hz, 1 H), 7.34-7.38 (m, 1 H), 7.52-7.56 (m, 1 H), 7.57-7.59 (m, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15852-73-0, its application will become more common.
Reference:
Patent; PFIZER INC.; PETTERSSON, Martin Youngjin; JOHNSON, Douglas Scott; SUBRAMANYAM, Chakrapani; O’DONNELL, Christopher John; AM ENDE, Christopher William; GREEN, Michael Eric; PATEL, Nandini Chaturbhai; STIFF, Cory Michael; TRAN, Tuan Phong; KAUFFMAN, Gregory Wayne; STEPAN, Antonia Friederike; VERHOEST, Patrick Robert; WO2015/49616; (2015); A1;,
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