Related Products of 616-29-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 616-29-5 as follows.
To a solution of l,3-diaminopropan-2-ol (5 g, 55.48 mmol) in MeOH (50 mL) was added TEA (16.84 g, 166.44 mmol, 23.17 mL) and Boc20 (31.48 g, 144.25 mmol, 33.14 mL) at 15 C. The mixture was stirred at 45C for 12 h under N2atmosphere. The reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, Petroleum ether/Ethyl acetate=20/l to 0: 1) to give /er/-butyl N-[3-(/er/- butoxycarbonylamino)-2-hydroxy-propyl] carbamate (15.47 g, 96.04% yield) as a white solid.1H NMR (400 MHz, CDCl3): d 5.03 (brs, 2H), 4.08-4.02 (m, 2H), 4.27 (s, 2H), 3.22-3.06 (m, 4H), 1.37 (s, 18H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,616-29-5, its application will become more common.
Reference:
Patent; ARBUTUS BIOPHARMA, INC.; BI, Yingzhi; DORSEY, Bruce D.; FAN, Yi; MOORE, Christopher Brooks; NGUYEN, Duyan; (169 pag.)WO2019/191624; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts