Application of 928-51-8, Adding some certain compound to certain chemical reactions, such as: 928-51-8, name is 4-Chlorobutan-1-ol,molecular formula is C4H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 928-51-8.
Example 6 Synthesis of 4-(nitrooxy)butyl 4-phenyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa- 1 ,4-dienyl)butanoate (Compound 6) Step 1 : Synthesis of 4-chlorobutyl 4-nitrobenzoate To a solution of 4-Chlorobutanol (1.09 g; 10.04 mmol) and TEA (1.7 ml; 12.05 mmol) in CH2C12 (25 ml) cooled at 0C, 4-Nitrobenzoyl chloride (2.23 g; 12.05 mmol) was added portionwise. The mixture was stirred 2 hours at room temperature then was washed with NaH2P04 (25 ml), H20 and brine. The residue was purified by flash chromatography (Biotage SPl instrument, SNAP cartridge silica 100 g, n-Hexane/EtOAc 9: 1, 10 CV) affording the title compound (2.48 g; Yield: 96%) 1H NMR (300 MHz, CDC13) delta 8.38-8.25 (m, 2H), 8.25-8.14 (m, 2H), 4.55-4.33 (m, 2H), 3.73-3.53 (m, 2H), 2.13-1.85 (m, 4H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 928-51-8, 4-Chlorobutan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NICOX SCIENCE IRELAND; ALMIRANTE, Nicoletta; STORONI, Laura; RONSIN, Gael; BASTIA, Elena; WO2014/170264; (2014); A1;,
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