Adding a certain compound to certain chemical reactions, such as: 2240-88-2, 3,3,3-Trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3,3,3-Trifluoropropan-1-ol
Intermediate S-i A: 3,3,3 -Trifluoropropyl trifluoromethanesulfonate Intermediate S-i A: 3,3,3 -Trifluoropropyl trifluoromethanesulfonateOF?3o (S-iA)[00136j To a cold (-25 °C), stirred solution of 2,6-lutidine (18.38 mL, 158 mmol) in DCM (120 mL) was added Tf20 (24.88 mL, 147 mmol) over 3 mm, and the mixture wasstirred for 5 mm. To the reaction mixture was added 3,3,3-trifluoropropan-i-ol (12 g,105 mmol) over an interval of 3 mm. After 2 hr, the reaction mixture was warmed to room temperature and stirred for 1 hr. The reaction mixture was concentrated to half its volume, then purified by loading directly on a silica gel column (330g ISCO) and the product was eluted with DCM to afford Intermediate S-iA (13.74 g, 53percent) as a colorlessoil. ?H NMR (400 MHz, CDC13) oe ppm 4.71 (2 H, t, J=6.i5 Hz), 2.49-2.86 (2 H, m).
The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HAN, Wen-Ching; GILL, Patrice; GAVAI, Ashvinikumar, V.; QUESNELLE, Claude, A.; WO2014/47393; (2014); A1;,
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