Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-20-8, name is Trichloroethanol. A new synthetic method of this compound is introduced below., COA of Formula: C2H3Cl3O
3alpha-Hydroxy-7-oxo-5beta-cholanoic acid (39.0 g, 100 mmol),beta,beta,beta-Trichloroethanol (16.4 g, 110 mmol)Soluble in 150 ml of methylene chlorideStir and cool to 0C.DCC (dicyclohexylcarbodiimide) (24.7 g) was slowly added dropwise.120mmol) dichloromethane solution,After dripping, the reaction was incubated for 6 hours.Filtered, concentrated under reduced pressure, recrystallized from acetonitrile, filtered,Trichloroethyl 3alpha-hydroxy-7-oxo-5beta-cholanoic acid (50.4 g, yield 86.7%) was obtained.
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Reference:
Patent; Hangzhou Heze Pharmaceutical Technology Co., Ltd.; Ni Sheng; Yang Zhenghe; Chen Jie; Cai Liefeng; Zhou Yinglei; Zhou Liang; Chen Hongxiang; (23 pag.)CN107383139; (2017); A;,
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