With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol, molecular formula is C7H5BrF2O, molecular weight is 223.0148, as common compound, the synthetic route is as follows.Quality Control of (4-Bromo-2,6-difluorophenyl)methanol
Potassium hydroxide (0.377 g, 6.73 mmol) was added to a solution of 6-iodohexan-2-one(80% purity) (2.374 g, 8.40 mmol) in toluene (0.5 mL), followed by the addition of 4-bromo-2,6-difluorobenzylalcohol (1.25 g, 5.60 mmol). The solution mixture was stirred overnight atroom temperature. Water (20 mL) was added to the solution mixture. The mixture was extracted with ethyl acetate (3 x30 mL), and the organic layers were combined, washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude was purified by column chromatography (dichloromethane/heptane 5:1 to dichloromethane/acetone 4:1) to give 774 mg (43%) of the product. MS (ESIj: m/z 321, 323[M+H]t
At the same time, in my other blogs, there are other synthetic methods of this type of compound,162744-59-4, (4-Bromo-2,6-difluorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; F2G LIMITED; SIBLEY, Graham Edward Morris; MALMSTROeM, Lars Jonas; LARSSON, Johanna Maria; (212 pag.)WO2017/9651; (2017); A1;,
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