Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below., Computed Properties of C6H13NO
To a round bottom flask with stir bar was added (S)-4-(1-(tert- butoxycarbonylamino)ethyl)-2-chlorobenzoic acid (450 mg, 1.20 mmol), (lr,4r)-4- aminocyclohexanol (415 mg, 3.60 mmol), EDO HCI (460 mg, 2.40 mmol), 1-hydroxy-7-aza- benzotriazole (229 mg, 1.68 mmol) and DMF (6 mL). To this mixture was then added DIEA (629 pL, 3.60 mmol). Reaction mixture was allowed to stir at room temperature for 18 hours. The reaction mixture was diluted with water and extracted with EtOAc. The organic phaseswere combined, washed with twice with water, brine, dried (Na2SO4), filtered and concentrated to a brown crystalline tert-butyl (S)- 1 -(3-chloro-4-((1 r,4S)-4- hydroxycyclohexylcarbamoyl)phenyl)ethylcarbamate (330 mg, 0.83 mmol, 69 % yield). LCMS m/z391.1 (M + H), RtO.71 mm.
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Reference:
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; SHAFER, Cynthia; SHULTZ, Michael David; WO2014/147586; (2014); A1;,
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