Application of 144-19-4 ,Some common heterocyclic compound, 144-19-4, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a 3.8 liter jacketed vessel, 424 grams of 2,2,4-trimethyl-1,3-pentanediol (TMPD Glycol) were charged and heated to a nominal temperature of 150 C. When the TMPD Glycol began to melt, the agitator was switched on to a speed of 400 rpm. In a separate vessel, 1674 grams of 2-ethylhexanoic acid (2-EH) was heated. When the temperature of the 2-EH reached 175 C., it was added to the TMPD Glycol forming a clear solution. The solution was heated until it reached 240 C. The temperature of the vessel contents was controlled by manipulating the temperature of the fluid in the vessel jacket. A sparge of nitrogen was established through a small pipe that discharged 50 cc/min of nitrogen to the base of the vessel under the impeller. Nitrogen purging was discontinued after 1 hours of operation. The pressure of the vessel was atmospheric (760 mmHg). A condenser located in the line between the vessel and the vacuum pump condensed any vapors in the gas and was collected in a receiver vessel where it separated into an aqueous and water layer. The organic layer comprising mainly 2-EH was returned to the vessel while the water layer was removed from the system. During the experiment, samples of the solution were taken at discrete intervals to monitor the progress of the reaction. The results of this experiment are shown in Table 10.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 144-19-4, 2,2,4-Trimethyl-1,3-pentanediol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Eastman Chemical Company; US7674931; (2010); B1;,
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