Application of 2807-30-9 ,Some common heterocyclic compound, 2807-30-9, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(1) Weigh 100g ethylene glycol mono-n-propyl ether,0.3 g of N, N-dimethylaniline,This was added to the reaction vessel with a reflux condenser,115.97 g of thionyl chloride (content of 99.3%, sulfuryl chloride content of 0.5%) was added to a constant pressure dropping funnel,Warming up to 35 C, turning on stirring,Thionyl chloride was slowly added dropwise to the reaction vessel to release sulfur dioxide and hydrogen chloride gas during the reaction,Control thionyl chloride dropping speed,The temperature of the reaction solution was maintained at 60 ± 5 C;(2) until the thionyl chloride is added dropwise,According to the reaction gas evolution rate gradually warmed to 95 ,Until no gas release, continue to heat 1h get crude,After the crude product is cooled down to 40 C, a certain amount of lye is added and stirred,The remaining thionyl chloride decomposition and neutralization of acid,Then add a certain amount of water for hydrolysis,After standing for liquid separation, 117.65 g of 2-propoxychloroethane was obtained.After testing, the chromatographic content of the product was 99.84%Yield of 99.89%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2807-30-9, 2-Propoxyethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shandong Kaisheng New Materials Co., Ltd.; Shi Yufei; Zhang Taiming; Han Nannan; Wang Ronghai; Xue Juqiang; Wang Jun; Li Guanghui; Huang Guiqing; (5 pag.)CN106831368; (2017); A;,
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