Related Products of 5259-98-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5259-98-3 as follows.
4-chlorobutan-1-ol (1.0 equiv, 46.05 mmol, 5.00 g) and sodium azide (2.0 equiv, 92.10mmol, 5.99g) were dissolved in Water (50 mL) and refluxed at 100°C overnight. Reaction progression was checked by TLC, which showed full conversion. The reaction was left to cool to room temperature and the product was extracted with diethylether (5x). The combined organic layers were washed with brine and dried with sodium sulfate. Concentration in vacuo yielded the desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5259-98-3, its application will become more common.
Reference:
Article; Saarbach, Jacques; Masi, Daniela; Zambaldo, Claudio; Winssinger, Nicolas; Bioorganic and Medicinal Chemistry; vol. 25; 19; (2017); p. 5171 – 5177;,
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