Electric Literature of 627-27-0, Adding some certain compound to certain chemical reactions, such as: 627-27-0, name is But-3-en-1-ol,molecular formula is C4H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-27-0.
PPh3 (95.5 g), phthalimide (56.1 g) and 3 -Buten-l-ol (25.0 g) were suspended in dry THF (250 mL) and cooled to 0 C. Diisopropyl azodicarboxylate (75.1 mL) was then added dropwise over a period of 20 min. The resulting mixture was stirred at 0 C for 30min and then at r.t. over night. Control by LC/MS showed product. THF was removed in vacuo as far as possible. The oily residue was diluted with PE/EtOAc = 9:1 (400 mL) and stirred vigourously until a precipitate occured. The precipitated OPPh3 was filtered off and washed extensively with PE/EtOAc = 9:1. The combined filtrates were filtered through a patch of SiO 2 and then evaporated. The residue was diluted with PE (200 mL), mixed vigourously and placed in an icebath. The precipitated product was then filtered off and washed with PE to afford the product in sufficent purity as pale yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-27-0, But-3-en-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; OMEICOS THERAPEUTICS GMBH; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MAX DELBRUeCK-CENTRUM FUeR MOLEKULARE MEDIZIN; FISCHER, Robert; KONKEL, Anne; WESSER, Tim; WESTPHAL, Philipp; SCHUNK, Wolf-Hagen; WESTPHAL, Christina; FALCK, John Russel; (121 pag.)WO2017/13265; (2017); A1;,
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