Adding a certain compound to certain chemical reactions, such as: 186020-66-6, tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 186020-66-6, blongs to alcohols-buliding-blocks compound. Quality Control of tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Second Step tert-Butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate tert-Butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate (488 mg, 1.75 mmol) and triethylamine (532 mg, 5.26 mmol) were dissolved in dichloromethane (15 mL), and tosyl chloride (435 mg, 2.28 mmol) was added. After the mixture was stirred at room temperature for 17 hours, the reaction mixture was concentrated, and the resultant residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:2) to obtain the title compound (550 mg, 73%) as colorless clear oil. LCMS: m/z 450[M+H2O]+ HPLC retention time: 0.90 minutes (analysis condition SQD-FA05)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,186020-66-6, its application will become more common.
Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; OHTAKE, Yoshihito; OKAMOTO, Naoki; ONO, Yoshiyuki; KASHIWAGI, Hirotaka; KIMBARA, Atsushi; HARADA, Takeo; HORI, Nobuyuki; MURATA, Yoshihisa; TACHIBANA, Kazutaka; TANAKA, Shota; NOMURA, Kenichi; IDE, Mitsuaki; MIZUGUCHI, Eisaku; ICHIDA, Yasuhiro; OHTOMO, Shuichi; HORIBA, Naoshi; (310 pag.)US2016/2251; (2016); A1;,
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