Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 558-42-9, blongs to alcohols-buliding-blocks compound. 558-42-9
EXAMPLE 121 4-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N-(2-hydroxy-2-methylpropyl)-N-methylthiophene-2-carboxamide (Compound 121) Step 1; 1-Chloro-2-methyl-2-propanol (103 muL, 1.00 mmol) was dissolved in a 40percent methylamine methanol solution (0.5 mL), and the mixture was stirred at 100¡ãC for 15 minutes at 100 W in a microwave-assisted chemical synthesis instrument (CEM Discover). After the mixture was left to cool to room temperature, the solvent was evaporated under reduced pressure. Then, acetonitrile (3 mL) was added to the residue, and the precipitated solid was removed by filtration. After an aqueous sodium hydrogen carbonate solution (10 drops) was added to the filtrate, the solvent was evaporated under reduced pressure to give a roughly purified product of 2-methyl-1-(methylamino)propan-2-ol. The roughly purified product was used in the subsequent step as such without purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,558-42-9, its application will become more common.
Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2090570; (2009); A1;,
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