With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, molecular weight is 89.1362, as common compound, the synthetic route is as follows.110-73-6
2-(ethyl(2-hydroxyethyl)amino)benzenesulfonamideTo the solution of 2-fluorobenzenesulfonamide (1051 mg, 6 mmol) in 2-(ethylamino)ethanol (2.93 mL, 30.0 mmol) was heated with microwave irradiation at 130 C for 30 min, heated again with microwave at 130 C for 30 min (71-1), heated again with microwave at 150 C for 30 min. To the reaction mixture was added DMSO (2 mL) and water (0.2 mL) then heated with microwave irradiation at 130 C for 2 h, heated again with microwave at 140 C for 1 h, heated again with microwave at 150 C for 1 h, heated again at 150 C for 5 h. The reaction mixture was diluted with H20 (30 mL), adjusted pH to ~5 with HCI (6 N then 1 N), extracted with EtOAc (3 x 30 mL). The organic layer was washed with brine (30 mL), dried over MgSO4, filtered, concentrated under reduced pressure, purified by silica gel chromatography, to afford the desired product 2-(ethyl(2-hydroxyethyl)amino)benzenesulfonamide (923.0 mg, 3.78 mmol, 63.0 % yield). LC-MS m/z 245 (M + H)+, 0.94 (ret. time).
Statistics shows that 110-73-6 is playing an increasingly important role. we look forward to future research findings about 2-(Ethylamino)ethanol.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; BOEHM, Jeffrey Charles; DAVIES, Thomas Glanmor; WOOLFORD, Alison Jo-anne; GRIFFITHS-JONES, Charlotte Mary; WILLEMS, Hendrika Maria Gerarda; NORTON, David; SAXTY, Gordon; HEIGHTMAN, Thomas Daniel; LI, Tindy; KERNS, Jeffrey K.; DAVIS, Roderick S.; YAN, Hongxing; WO2015/92713; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts