558-42-9, Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 558-42-9, blongs to alcohols-buliding-blocks compound.
To a stirred solution of 177 (3.4 g, 12.0 mmol) in dry DMF (20 mL), Cs2CO3 (7.7 g, 24.0 mmol) and l-chloro-2-methylpropan-2-ol 179 (1.6 g, 14.0 mmol) were added and heated at 90¡ãC for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with water and extracted with EtOAc. The combined organic layer were washed with brine, dried over anhydrous Na2S04 and concentrated under reduced pressure to afford 180. Yield: 1.7 g, 40percent. 1H NMR (400 MHz, DMSO-d6) delta 1.06 – 1.11 (m, 4H), 1.21 (s, 6H), 2.13 – 2.22 (m, 2H), 2.55 – 2.60 (m, 1H), 3.01 (1920) – 3.07 (m, 1H), 3.76 (s, 2H), 4.84 – 4.94 (m, 2H), 5.00 – 5.19 (m, 1H), 5.53-5.60 (m, 1H), 6.91 (1921) – 6.98 (m, 1H), 7.10 – 7.18 (m, 1H), 7.24 – 7.31 (m, 1H), 8.26 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,558-42-9, its application will become more common.
Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; (500 pag.)WO2018/98206; (2018); A1;,
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