627-18-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-18-9, name is 3-Bromopropan-1-ol, molecular formula is C3H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Synthesis of Compound (1b):At less than 0 C,Dihydroartemisinin (840 mg, 3.0 mmol) and 3-bromo-1-propanol (0.42 mL, 4.6 mmol)Dissolved in CH2Cl2 (20 mL), BF3¡¤Et2O (0.63 mL, 5.0 mmol) was added dropwise.After the dropwise addition, stirring was continued for 5 min at the same temperature, and then transferred to an ice water bath.Stirring was continued for about 50 minutes. After the reaction is over,Wash with saturated NaHCO3 solution, water and saturated brine.The organic layer was collected and dried over anhydrous sodium sulfate.Concentrate to a pale yellow oily crude product.The crude product was chromatographed on silica gel (ethyl acetate: petroleum ether = 3:97)A colorless solid (471 mg, 39%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-18-9, 3-Bromopropan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guangzhou University Of Traditional Chinese Medicine (Guangzhou Traditional Chinese Medicine Institute); He Xixin; Pi Rongbiao; Li Mingtao; Zhong Xiaolin; Luo Huijuan; Wang Jiamin; (12 pag.)CN108586480; (2018); A;,
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