As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 124-68-5, name is 2-Amino-2-methyl-1-propanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 124-68-5
Step 1 Synthesis of benzyl 1-hydroxy-2-methylpropan-2-ylcarbamate 3.0 g of 2-amino-2-methylpropan-1-ol was dissolved in 100 mL of dichloromethane, and 100 mL of water and 8.4 g of sodium bicarbonate were then added. To this solution, 5.7 g of benzyl chloroformate was added dropwise, and the mixture was stirred at room temperature for 16 hours. After extraction with dichloromethane (100 mL*3), the extract was dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated, and the obtained crude product was purified by silica gel column chromatography (ethyl acetate_hexane=1:1) to obtain 7.6 g of the compound of interest as a colorless oil (86%). 1H-NMR spectrum (CDCl3, delta ppm): 1.28 (s, 6H), 1.51 (br s, 1H), 3.60 (d, J=6.0 Hz, 2H), 5.29 (s, 2H), 6.12 (s, 1H), 7.26-7.38 (m, 5H)
The chemical industry reduces the impact on the environment during synthesis 124-68-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; D. WESTERN THERAPEUTICS INSTITUTE, INC; US2012/35159; (2012); A1;,
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