Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of (5-Ethyl-1,3-dioxan-5-yl)methanol5187-23-5, Name is (5-Ethyl-1,3-dioxan-5-yl)methanol, SMILES is CCC1(CO)COCOC1, belongs to alcohols-buliding-blocks compound. In a article, author is Xin, Yue, introduce new discover of the category.
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice
Alcoholic liver disease (ALD) occurs as a result of chronic and excessive alcohol consumption. It encompasses a wide spectrum of chronic liver abnormalities that range from steatosis to alcoholic hepatitis, progressive fibrosis and cirrhosis. Endoplasmic reticulum (ER) stress induced by ethanol metabolism in hepatocytes has been established as an important contributor to the pathogenesis of ALD. However, whether SIRT6 exerts regulatory effects on ethanol-induced ER stress and contributes to the pathogenesis of ALD is unclear. In this study, we developed and characterized Sirt6 hepatocyte-specific knockout and transgenic mouse models that were treated with chronic-plus-binge ethanol feeding. We observed that hepatic Sirt6 deficiency led to exacerbated ethanol-induced liver injury and aggravated hepatic ER stress. Tauroursodeoxycholic acid (TUDCA) treatment remarkably attenuated ethanol-induced ER stress and ameliorated ALD pathologies caused by Sirt6 ablation. Reciprocally, SIRT6 hepatocyte-specific transgenic mice exhibited reduced ER stress and ameliorated liver injury caused by ethanol exposure. Consistently, knockdown of Sirt6 elevated the expression of ER stress related genes in primary hepatocytes treated with ethanol, whereas overexpression of SIRT6 reduced their expression, indicating SIRT6 regulates ethanol-induced hepatic ER stress in a cell autonomous manner. Collectively, our results suggest that SIRT6 is a positive regulator of ethanol-induced ER stress in the liver and protects against ALD by relieving ER stress. (C) 2021 Elsevier Inc. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5187-23-5. Application In Synthesis of (5-Ethyl-1,3-dioxan-5-yl)methanol.
Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts