In an article, author is Kong, Qingyao, once mentioned the application of 124-76-5, Category: alcohols-buliding-blocks, Name is Isoborneol, molecular formula is C10H18O, molecular weight is 154.2493, MDL number is MFCD00074821, category is alcohols-buliding-blocks. Now introduce a scientific discovery about this category.
Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform
Alcohol use disorder (AUD) is one of the foremost public health problems. Alcohol is also frequently co-abused with cocaine. There is a huge unmet need for the treatment of AUD and/or cocaine co-abuse. We recently demonstrated that skin grafts generated from mouse epidermal stem cells that had been engineered by CRISPR-mediated genome editing could be transplanted onto mice as a gene delivery platform. Here, we show that expression of the glucagon-like peptide-1 (GLP1) gene delivered by epidermal stem cells attenuated development and reinstatement of alcohol-induced drug-taking and seeking as well as voluntary oral alcohol consumption. GLP1 derived from the skin grafts decreased alcohol-induced increase in dopamine levels in the nucleus accumbens. In exploring the potential of this platform in reducing concurrent use of drugs, we developed a novel co-grafting procedure for both modified human butyrylcholinesterase (hBChE)- and GLP1-expressing cells. Epidermal stem cell-derived hBChE and GLP1 reduced acquisition of drug-taking and toxicity induced by alcohol and cocaine co-administration. These results imply that cutaneous gene delivery through skin transplants may add a new option to treat drug abuse and co-abuse.
If you are interested in 124-76-5, you can contact me at any time and look forward to more communication. Category: alcohols-buliding-blocks.
Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts