Dual-responsive nanogels based on oligo(ethylene glycol) methacrylates and acidic co-monomers was written by Macchione, Micaela A.;Sacarelli, M. Florencia;Racca, Ana C.;Biglione, Catalina;Panzetta-Dutari, Graciela M.;Strumia, Miriam C.. And the article was included in Soft Matter in 2019.Formula: C16H26O7 This article mentions the following:
Ethylene glycol-based nanogels (NGs) have demonstrated their potential for the development of next-generation formulations for biomedical applications due to their interesting properties. In this work, monodispersed NGs based on oligo(ethylene glycol) methacrylates (OEG) were synthesized through free radical precipitation/dispersion polymerization assisted by ultrasonication. Di(ethylene glycol)methyl ether methacrylate (DEGMA) and oligo(ethylene glycol) methacrylate (OEGMA; Mn 475 g mol-1) were used as the main monomers, acrylic acid (AA) or itaconic acid (IA) as co-monomers (OEG-co-AA and OEG-co-IA, resp.) and tetraethylene glycol dimethacrylate (TEGDMA) as crosslinker. The physicochem. properties of OEG-co-AA and OEG-co-IA NGs were studied including hydrodynamic diameter, poly-dispersity index, zeta potential and pH/temperature responsiveness. Samples with 4 mol% of both AA and IA showed nanometric sizes. Regarding their thermo-responsiveness, unexpected differences between NGs with AA or with IA were observed Besides, NGs did not impair the cell viability of a breast tumor cell line even when high concentrations were added to the culture medium. The properties of the synthesized NGs showed that either NGs with 4% AA or with 4% IA are outstanding candidates for biomedical applications. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).
((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C16H26O7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts