Readily Accessible and Highly Efficient Ferrocene-Based Amino-Phosphine-Alcohol (f-Amphol) Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones was written by Yu, Jianfei;Duan, Meng;Wu, Weilong;Qi, Xiaotian;Xue, Peng;Lan, Yu;Dong, Xiu-Qin;Zhang, Xumu. And the article was included in Chemistry – A European Journal in 2017.Quality Control of (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:
We have successfully developed a series of novel and modular ferrocene-based amino-phosphine-alc. (f-Amphol) ligands and applied them to iridium-catalyzed asym. hydrogenation of various simple ketones to afford the corresponding chiral alcs. with excellent enantioselectivities and conversions (98-99.9 % ee, >99 % conversion, turnover number up to 200,000). Control experiments and d. functional theory (DFT) calculations have shown that the hydroxyl group of our f-Amphol ligands played a key role in this asym. hydrogenation. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Quality Control of (R)-1-(3-Chlorophenyl)ethanol).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of (R)-1-(3-Chlorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts