Bottlebrush polymers with self-immolative side chains was written by Wu, Ying;Zhang, Liangcai;Zhang, Minghui;Liu, Zhengping;Zhu, Wen;Zhang, Ke. And the article was included in Polymer Chemistry in 2018.Electric Literature of C7H7NO4 This article mentions the following:
A series of bottle-brush polymers with self-immolative side chains were prepared by a grafting-onto method. Poly(3-azido-2-hydroxypropyl methacrylate) (PGA) and propargyl-capped poly(carbamates) were used as the backbone and side chains, resp. A copper-catalyzed azide-alkyne cycloaddition reaction was used to graft the side chains onto the backbone with a high grafting d. A UV cleavable o-nitrobenzyl (ONB) linker was designed at the junction site of the backbone and side chain. Under UV irradiation, the ONB linkers cleaved to break the bottle-brush mol. architecture by detaching phenylamine terminated side chains from PGA backbones. The self-immolative disassembly of the detached side chains was then followed to generate aromatic amine small mols. The model functional bottle-brush polymers were further constructed using acrylate substituted poly(carbamates) as side chains, whose self-immolative disassembly continuously released fluorescence signals. Moreover, the total disassembly rate of the bottle-brush polymers could be conveniently tuned by tailoring the substituent group of poly(carbamate) side chains. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Electric Literature of C7H7NO4).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C7H7NO4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts