Cardioprotective effect of rheum turkenstanicum against doxorubicin-induced toxicity in rats was written by Hosseini, Azar;Safari, Mohammad-Kazem;Rajabian, Arezoo;Boroumand-Noughabi, Samaneh;Eid, Ali H.;Al Dhaheri, Yusra;Gumpricht, Eric;Sahebkar, Amirhossein. And the article was included in Frontiers in Pharmacology in 2022.Synthetic Route of C14H12O4 This article mentions the following:
Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum turkestanicum (R.turkestanicum) extract against doxorubicin cardiotoxicity due to its considerable in vitro antioxidant activity. Male Wistar rats received 2.5 mg/kg doxorubicin i.p. every otherday for 2 wk to create an accumulative dose. R. turkestanicum was administrated at a dose of 100 and 300 mg/kg i.p. from the second week for 7 days. On the 15th day, the animals were anesthetized and blood was collected from cardiac tissue for evaluation of alanine aminotransferase (ALT), cardiac muscle creatinine kinase (CK-MB), troponin T (cTn-T), lactate dehydrogenase (LDH), and B-type natriuretic peptide brain natriuretic peptide. A cardiac homogenate was also collected to determine superoxide dismutase (SOD), catalase Catalase Activity, malondialdehyde (MDA), and thiols. Histopathol. was also performed. Doxorubicin increased all cardiac enzymes and malondialdehyde, correlating with a reduction in SOD, catalase, and thiols. Histopathol. revealed extracellular edema, moderate congestion, and hemorrhage of foci. In contrast, administration of R. turkestanicum ameliorated these doxorubicin-induced pathophysiol. changes. This study revealed that the extract ameliorated doxorubicin-induced cardiac toxicity via modulation of oxidative stress-related pathways. Liquid chromatog.-mass spectrometry anal. of R. turkestanicum indicated several components with potent pharmacol. properties. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Synthetic Route of C14H12O4).
(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C14H12O4
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