Visible-light-induced radical cascade reaction to prepare oxindoles via alkyl radical addition to N-arylacryl amides was written by Cheng, Hanchao;Luo, Yunfeng;Lam, Tsz-Lung;Liu, Yungen;Che, Chi-Ming. And the article was included in Organic Chemistry Frontiers.Formula: C10H20O This article mentions the following:
A photochem. approach towards oxindoles I (R = H, OMe; R1 = H, SMe, Br, Bz, etc.; RR1 = -N=CHS-; R2 = H, OMe; R3 = H; R2R3 = -CH=CH-CH=CH-; R4 = Me, 2-cyanoethyl, Ph, Bn; R3R4 = -(CH2)3-; R5 = 2-(4-methoxyphenyl)-2-oxoethyl, 1,1,2,2,3,3,4,4,4-nonafluorobutyl, 2-(1-benzofuran-2-yl)-2-oxoethyl, etc.) by the radical cascade reaction of α,β-unsaturated N-arylacryl amides with alkyl bromides or iodides upon visible light irradiation was described. This transition metal- and photosensitizer-free protocol afforded diverse oxindoles I with C3 quaternary centers in high product yields under mild reaction conditions. Importantly, the method was applicable to prepare the core skeletons of (±)-physovenine, (±)-esermethole and (±)-physostigmine. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C10H20O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts