Synthesis and Characterization of an Antibacterial Hydrogel Containing Covalently Bound Vancomycin was written by Lakes, Andrew L.;Peyyala, Rebecca;Ebersole, Jeffrey L.;Puleo, David. A.;Hilt, J. Zach;Dziubla, Thomas D.. And the article was included in Biomacromolecules in 2014.Name: Diethyleneglycoldiacrylate This article mentions the following:
The release of freely loaded small mols. from biomaterials often exhibits an initial burst, inhibiting the ability of these materials to match drug release with the biomaterial’s degradation period. In terms of antibiotic release systems, the remaining vehicle may become a substrate for colonization by bacterial biofilms once the payload is depleted, which can become life threatening. Secondary surgeries are typically performed to remove these empty depots as a means of preventing this type of infection. To maintain the effectiveness of a locally delivered antibiotic without the drawback of a second surgery, we propose a hydrogel drug delivery system in which the drug release rate of vancomycin and degradation rate of the hydrogel are linked via covalent incorporation of vancomycin in the hydrogel backbone. This was achieved through coupling PEG based monomer with vancomycin to create poly(β-amino ester) chem. and verified through drug release and matrix degradation studies. Antibiotic release and material degradation were tunable via hydrophobic/hydrophilic content of the hydrogel matrix and extended up to 3 wk in PBS sink conditions. Covalent addition of vancomycin to the hydrogel polymer backbone was verified through mass spectroscopy and HPLC peak addition, as well as radiotracing of collected HPLC fractions. Bioactivity of released vancomycin was also confirmed alongside the resulting antimicrobial activity of the reacted vancomycin releasate. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Name: Diethyleneglycoldiacrylate).
Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: Diethyleneglycoldiacrylate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts