Cobalt-catalyzed alkoxycarbonylation of ethers: Direct synthesis of α-oxy esters from phenols and alcohols was written by Wang, Le-Cheng;Xu, Jian-Xing;Wu, Xiao-Feng. And the article was included in Journal of Catalysis in 2022.Formula: C10H20O This article mentions the following:
A cobalt-catalyzed direct alkoxycarbonylation of ethers (such as THF, 1,4-dioxane, ethoxyethane, etc.) has been accomplished. This new catalytic system allows the use of ethers, important building blocks in organic synthesis, as the carbonylation substrates. A variety of phenols and alcs. ROH was transformed to the corresponding α-oxy ester derivatives ROC(O)R1 (R1 = oxolan-2-yl, 1,4-dioxan-2-yl, 1-ethoxyethyl, etc.; R = Ph, naphthalen-2-yl, pyridin-3-yl, adamantan-1-yl, etc.) in high yields with excellent functional group tolerance. In addition, several pharmaceutical and bioactive mol. related compounds were also suitable substrates for this carbonylation process, and the target products were obtained in good yields. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C10H20O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts