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27489-62-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

(To a reaction flask, DMF (2 L) was added, 2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-chloro-4-methoxybenzylamino)pyrimidine-5-carboxylic acid (300 g, 0.8 mol) was added under stirring, DIEA (209 mL, 1.2 mol) was added dropwise under ice-water, then HATU (456 g, 1.2 mol) was added, the mixture was stirred for 30 min, trans-4-aminocyclohexanol (138.2 g, 1.2 mol) was added. The temperature of the reaction was naturally elevated to room temperature, stirring was carried out for 2 h, and TLC was used to monitor the reaction. After the end of reaction, the reaction liquid was poured into water (3 L) to precipitate solid and filtrated, the filter cake was washed with water, air-dried, then recrystallized with acetone twice to obtain white solid (240 g, yield of 63%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; XUANZHU PHARMA CO., LTD.; Shu, Chutian; Wu, Yongqian; (34 pag.)US2016/46654; (2016); A1;,
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