Selectfluor-Enabled C(sp3)-H Alkoxylation of 3-Methylfuranocoumarins was written by Qin, Zengxin;Zhao, Mengfei;Zhang, Kaixin;Goto, Masuo;Lee, Kuo-Hsiung;Li, Jizhen. And the article was included in Journal of Organic Chemistry in 2021.COA of Formula: C7H6Cl2O This article mentions the following:
A facile and metal-free method for the direct C(sp3)-H bond alkoxylation of 3-methylfuranocoumarins I (R = H, Me, NO2; R1 = H; R2 = H; R1R2 = -CH=CH-CH=CH-; R3 = H, Me) and 4,17-dimethyl-11,15-dioxacyclopenta[a]phenanthren-12-one with alcs. R4OH (R4 = iso-Pr, cyclopentyl, 3-(2-bromophenyl)propyl, etc.) has been disclosed. Selectfluor enabled the (hetero)benzylic C-H etherification by tuning the reaction temperature and solvent. Various alcs. were compatible in this transformation with suitable yields. The mechanistic studies revealed that the reaction might undergo the double addition process of alcs., as well as the departure of a fluoride anion and the formation of an oxonium ion. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8COA of Formula: C7H6Cl2O).
(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C7H6Cl2O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts