Base-induced Sommelet-Hauser rearrangement of N-(pyridinylmethyl) tetraalkylammonium salts was written by Tayama, Eiji;Shimizu, Goshu;Nakao, Ryo. And the article was included in Tetrahedron in 2022.Formula: C7H9NO This article mentions the following:
The base-induced Sommelet-Hauser (S-H) rearrangement of various types of N-(pyridinylmethyl) tetraalkylammonium salts to produce N,N-dialkyl-伪-pyridinylamino acid esters were investigated. For example, a treatment of N-(2-pyridinylmethyl) glycine tert-Bu ester-derived tetraalkylammonium salt with 1.2 equiv of potassium tert-butoxide in THF at -40掳C gave the corresponding S-H product, I [R = Obut; R1 = R2 = Me; R3= H] in 93% yield. Method was an efficient C-H functionalization of pyridines under simple and mild conditions. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Formula: C7H9NO).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C7H9NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts