115-20-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115-20-8, name is Trichloroethanol. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of a dicyclohexyl carbodiimide (3.26 g, 15.8 mmol), 4-n-butylbenzoic acid (2.35 g, 13.2 mmol) and 4-dimethylaminopyrridine (806.3 mg, 6.6 mmol) in anhydrous CH2Cl2 (100 mL), 2,2,2-trichloroethanol (1.5 mL, 15.8 mmol) was added dropwise at 0 C. The mixture was stirred at room temperature for 21 h. The reaction mixture was filtrated through funnel padded with cotton. The mixture was extracted with CH2Cl2 (30 mL), 1 mol/L HCl (25 mL¡Á2), then aqueous NaHCO3 solution (50 mL¡Á2), dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash silica gel columun chromatography (n-hexane/EtOAc=20/1) to give 3i as a colorless oil (3.39 g, 82%); IR (ATR, cm-1) : 2956, 2931, 2860, 1731, 1610, 1576, 1509; 1H NMR (500 MHz; CDCl3): delta8.04 (d, 2H, J = 8.0 Hz), 7.29 (d, 2H, J = 8.0 Hz), 4.96 (s, 2H), 2.69 (t, 2H, J = 7.8 Hz), 1.65-1.59(m, 2H), 1.38-1.34 (m, 2H), 0.93 (t, 3H, J = 7.5 Hz); 13C NMR (125 MHz; CDCl3): delta 165.1, 149.8,130.3, 128.8, 126.2, 95.3, 74.5, 35.9, 33.4, 22.4, 14.0; MS (EI) m/z (%). [M+], 308 (17) 273 (9) 267(19) 230 (5) 161 (99) 135 (14) 125 (15) 118 (30) 103 (18) 95 (6) 91 (72) 77 (19) 65 (10) 51 (6) 41(21). HRMS (EI): calcd for C13H15O2Cl3 [M+]: 308.0138; found: 308.0140.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115-20-8, Trichloroethanol.
Reference:
Article; Sawama, Yoshinari; Imanishi, Takahiro; Nakatani, Ryosuke; Fujiwara, Yuta; Monguchi, Yasunari; Sajiki, Hironao; Tetrahedron; vol. 70; 30; (2014); p. 4540 – 4546;,
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