Enantioselective Fluorescent Recognition in the Fluorous Phase: Enhanced Reactivity and Expanded Chiral Recognition was written by Wang, Chao;Wu, Elaine;Wu, Xuedan;Xu, Xiangchuan;Zhang, Guoqing;Pu, Lin. And the article was included in Journal of the American Chemical Society in 2015.Safety of (R)-2-Aminobutan-1-ol This article mentions the following:
A novel perfluoroalkyl-BINOL-based chiral diketone is the 1st highly enantioselective fluorescent sensor in the fluorous phase. One enantiomer of a chiral amino alc. or diamine at a concentration >1 mM can cause an up to 1200-2000-fold fluorescent enhancement of the sensor (0.08 mM), while the other enantiomer gives only a 10-50-fold enhancement. The fluorous-phase-based sensor is found to enhance the reactivity of the previously reported fluorous insoluble sensor with amino alcs. and expand its chiral recognition ability. Dynamic light scattering studies show the formation of aggregates of very different particle sizes when two enantiomers of a substrate interact with the sensor in perfluorohexane (FC-12). This substantial difference enables easy discrimination of the enantiomers with UV-lamps or even the naked eye. NMR, IR, and mass spectroscopic studies indicate that the fluorescent enhancement and enantioselectivity should originate from the fluorous solvent-promoted nucleophilic addition of the amino alcs. to the carbonyl groups of the sensor. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Safety of (R)-2-Aminobutan-1-ol).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Safety of (R)-2-Aminobutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts