Ruthenium-Catalyzed N-Alkylation for the Synthesis of 2-N-Pyridylmethyl Benzonitriles and an Exploration of Its Synthetic Utility was written by Chen, Mengmeng;Zhang, Min;Xie, Feng;Wang, Xiaoting;Jiang, Huanfeng. And the article was included in ChemCatChem in 2014.Reference of 1122-71-0 This article mentions the following:
The N-alkylation of 2-aminobenzonitriles with pyridyl methanols as the alkylating reagents has been demonstrated by using an easily available Ru3(CO)12/Binap/tBuOK [Binap=2,2′-bis(diphenylphosphino)-1,1′-binaphthyl] catalyst system. The synthetic protocol can be used to synthesize various 2-N-pyridylmethyl benzonitriles I (R1 = H, 6-Me, 4-Cl; R2 = H, 4-Me, 4,5-(OMe)2, etc.) in moderate to good isolated yields. Through an exploration of its synthetic utility, a novel straightforward synthesis of biol. interesting 2,3-diaryl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ones is demonstrated, which provides an important basis for the discovery of new bioactive compounds In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Reference of 1122-71-0).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 1122-71-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts